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KMID : 1143120170070010042
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Asia Pacific Allergy
2017 Volume.7 No. 1 p.42 ~ p.47
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The impact of age on Pru p 3 IgE production in Italy
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Ciprandi Giorgio
De Amici Mara
Di Martino Maria Luisa
Barocci Fiorella
Comite Paola
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Abstract
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Background: Pollen allergy may be frequently associated with fruit-vegetables: the so-called pollen food syndrome. Pru p 3 is the most relevant peach allergen. Previously, it has been reported that serum specific IgE level to Pru p 3 depends on age in a limited geographic area.
Objective: This study aimed to to test the hypothesis about the differences of Pru p 3 sensitization across Italy, mainly concerning the impact of age.
Methods: The current study was retrospective and multicentre, involving 2 labs in Northern Italy (709 subjects), 1 in Genoa (1,040 subjects), and 1 in Southern Italy (2,188 subjects). All of them referred to labs for IgE testing because of suspected food allergy. Serum IgE to Pru p 3 was assessed in all subjects.
Results: Sixteen point seven percent (16.7%) of subjects were sensitized to Pru p 3. Sensitization percentage sigificantly decreased over time. The serum IgE levels increased up to young adulthood and then decreased until aging.
Conclusion: Our experience demonstrates that Pru p 3 sensitization and production are closely age-dependent phenomena.
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KEYWORD
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Pru p 3, Lipid transfer protein, Sensitization, Age, Italy
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